Friday, March 1, 2013

Video: New hope for couples trying to conceive



>>> for couples who want to become parents but have troubles conceiving, in vitro fertilization can make the dream of a family come true. but there are high failure rates and costs to contend with. now amazing new technology like we have never seen before is helping to take some of the guesswork out of ivf . our chief medical editor, dr. nancy snyderman , reports.

>> ed and caroline mark started dating in college.

>> this is 1999 .

>> yeah, sophomore year, beginning of sophomore year.

>> they fell in love and got married, bound by common goals and shared values.

>> we knew we wanted to settle down in the midwest and raise a family.

>> after moving to ohio, the couple tried to get pregnant and when it didn't work, they went to the cleveland clinic for in vitro fertilization. there, they were among the first to use a remarkable new technology called an embryo scope, allowing researchers to monitor the development of fertilized eggs around the clock.

>> the embryo is extremely dynamic. it changes constantly, so there is a lot going on behind the scenes that if you just had a single static observation per day, you would miss.

>> traditionally, embryos are removed from the incubator once a day for a few minutes of observation. giving researchers limited chance to track changes prior to implantation. the embryoscope takes high-resolution pictures every 20 minutes for an almost real-time look at the cells which never leave the climate-controlled chamber. that access allows doctors to better see which embryos might have the best chance of becoming healthy babies.

>> it's amazing. we are learning a lot about embryos. we're seeing things that would not have been possible before.

>> while there's no evidence yet that growing cells in the embryoscope leads to a greater number of successful ivf pregnancies, ed and caroline marks, now parents of twins, claire and charlotte, believe it made all the difference.

>> you're seeing them go from a fertilized egg to that first split, and it's starting to grow into a baby. and it's just amazing that we actually got to see that.

>> the girls were born in december, and while the story of their birth will always be touched by technology, what ed and caroline see now is the family they always wanted. the fda approved this technology in 2011 , and it's now in about 15 reproductive centers around the country. the cost of ivf really varies across the country, but at the cleveland clinic , the use of them brioscope is just part of doing normal business now and it's pretty amazing.

>> science is blinding. dr. nancy snyderman , thank you, as always.

Source: http://www.nbcnews.com/video/nightly-news/50997885/

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Senate Democrats, GOP to stage votes on rival cuts

FILE - In this Feb. 26, 2013 file photo, Senate Majority Leader Harry Reid of Nev. speaks on Capitol Hill in Washington. President Barack Obama will meet Friday with the top leaders in the House and Senate to discuss what to do about automatic cuts to the federal budget, White House and congressional leaders said. The meeting is set to take place hours after the $85 billion in across-the-board cuts will have officially kicked in. This suggests both sides are operating under the assumption a deal won't be reached to avert the cuts ahead of the March 1 deadline. (AP Photo/J. Scott Applewhite, File)

FILE - In this Feb. 26, 2013 file photo, Senate Majority Leader Harry Reid of Nev. speaks on Capitol Hill in Washington. President Barack Obama will meet Friday with the top leaders in the House and Senate to discuss what to do about automatic cuts to the federal budget, White House and congressional leaders said. The meeting is set to take place hours after the $85 billion in across-the-board cuts will have officially kicked in. This suggests both sides are operating under the assumption a deal won't be reached to avert the cuts ahead of the March 1 deadline. (AP Photo/J. Scott Applewhite, File)

(AP) ? Across-the-board spending cuts all but certain, Republicans and Democrats in the Senate are staging a politically charged showdown designed to avoid public blame for any resulting inconvenience or disruption in government services.

The two parties drafted alternative measures to replace the cuts, but officials conceded in advance the rival measures were doomed.

At the White House, President Barack Obama invited congressional leaders to discuss the issue with him on Friday ? deadline day for averting the cuts, which would slash $85 billion from the military and domestic programs alike.

Democrats controlling the Senate are pushing a $110 billion plan that would block the cuts through the end of the year. They would carve 5 percent from domestic agencies and 8 percent from the Pentagon but would leave several major programs alone, including Social Security, Medicaid and food stamps, while limiting the cuts to Medicare to a 2 percent reduction to health care providers like doctors and hospitals.

The Democratic plan proposes $27.5 billion in future-year cuts in defense spending, elimination of a program of direct payments to certain farmers, and a minimum tax rate on income exceeding $1 million as the main elements of an alternative to the immediate and bruising automatic cuts, known in Washington-speak as a "sequester."

Republicans were sure to kill the Democratic alternative with a filibuster. They were poised to offer an alternative of their own that would give Obama the authority to propose a rewrite to the 2013 budget to redistribute the cuts. Obama would be unable to cut defense by more than the $43 billion reduction that the Pentagon faces and would be unable to raise taxes to undo the cuts.

The idea is that money could be transferred from lower-priority accounts to accounts funding air traffic control or meat inspection. The White House says such moves would offer only slight relief, but they could take pressure off Congress to address the sequester.

Democrats are sure to vote the GOP measure down. Both the House and the Senate are set to send their members home Thursday afternoon, even as the deadline to avoid the cuts looms the next day. Though bound to fail, the rival votes will allow both sides to claim they tried to address the cuts even as they leave them in place and exit Washington for a long weekend.

Obama on Wednesday summoned top congressional leaders for a White House meeting on Friday. Given longstanding, intractable differences over Obama's insistence that new tax revenues help replace the cuts, the meeting was not expected to produce a breakthrough.

Another topic for Friday's discussion is how to avoid Washington's next crisis, which threatens a government shutdown after March 27, when a six-month spending bill enacted last year expires.

Republicans are planning for a vote next week on a bill to fund the day-to-day operations of the government through the Sept. 30 end of the 2013 fiscal year, while keeping in place the $85 billion in automatic cuts.

The need to keep the government's doors open and lights on ? or else suffer the first government shutdown since 1996 ? requires the GOP-dominated House and the Democratic-controlled Senate to agree. Right now they hardly see eye to eye.

The House GOP plan, unveiled to the rank and file Wednesday, would award the Pentagon and the Veterans Affairs Department with their line-by-line budgets, for a more-targeted rather than indiscriminate batch of military cuts.

But it would deny domestic agencies the same treatment, which has whipped up opposition from veteran Democratic senators on the Appropriations Committee. Domestic agencies would see their budgets frozen, which would mean no money for new initiatives such as cybersecurity or for routine increases for programs such as low-income housing.

"We're not going to do that," said Sen. Tom Harkin, D-Iowa. "Of course not."

By freezing budgets for domestic agencies, the Republican plan would also deny additional money to modernize the U.S. nuclear arsenal and to build new Coast Guard cutters. GOP initiatives such as more money for the Small Business Administration or fossil fuels research would be hurt as well, but there's little appetite for the alternative, which is to stack more than $1 trillion worth of spending bills together for a single up-or-down vote.

The GOP move to add the line-by-line spending bills for the Pentagon and veterans programs to the catchall spending bill would give the military much-sought increases for force readiness and the VA additional funding for health care.

But that approach has few fans in the White House, which is seeking money to implement Obama's signature efforts to overhaul financial regulation and the nation's health care system, or the Democratic Senate, where veteran members of the Appropriations Committee want to add a stack of bills covering domestic priorities like homeland security, NASA and federal law enforcement agencies like the FBI.

"You need balance," said Sen. Chuck Schumer, D-N.Y. "We feel as strongly about the domestic side as we do defense."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-02-28-Budget%20Battle/id-1755782746fa40ea86d1764ebf876307

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3D? Feh. MIT has already moved on to 4D printing (video)

3D Feh MIT has already moved on to 4D printing video

The bad news: just as much of the world is starting to get excited about the prospects of 3D printing, science is moving on to the world of 4D. The good news: in the future, you might not have to assemble that Ikea chair yourself. "4D printing" is the term cientists are using to refer to a technology that MIT's Skylar Tibbits talked up during a recent TED appearance. The fourth "d" here is time, referring to an object that, once printed, is capable of changing shape (over time, naturally).

"Essentially the printing is nothing new," Tibbits told the BBC. "It is about what happens after." So far the concept has been demonstrated with thin strands of plastic, which, once added to water, form into a predetermined shape, using energy from the absorption. Suggested future applications involve furniture, pipes, bikes and buildings. First, however, scientists will have to demonstrate the technology on a larger structure, of course, and they'll explore the possibility of other energy sources, like heat, sound and vibration.

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Source: BBC

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/AfGe1W2KjIA/

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AP Source: Salary cap increases to $123 million

The NFL salary cap for the 2013 season will rise to $123 million from $120.6 million in 2012, an NFL Players Association official familiar with negotiations over the figure told The Associated Press on Thursday.

The official spoke to the AP on condition of anonymity because no formal announcement had been made.

The increase, which is larger than some in the NFL had anticipated, is a result of greater-than-expected revenues last season ? primarily from NFL Properties ? and a jump in projected league revenues, according to the official.

The league and the union work together to establish a cap number, based on parameters established under their collective bargaining agreement. The current 10-year CBA was signed in August 2011, ending the owners' lockout of the players.

One of the main areas of contention during that labor dispute was how to divide the more than $9 billion in annual league revenues, a figure that will keep rising, particularly once the NFL's new television contracts kick in for the 2014 season. Those additional revenues will be reflected in the salary cap for 2015, which is expected to see a more significant increase than the roughly 2 percent uptick from 2012 to 2013.

There was no salary cap in 2010, the final year of the old CBA. In 2011, the first year under the present deal, the figure was $120.375 million.

Over the next four seasons, from 2013-16, each of the NFL's 32 clubs will be required to spend an average of at least 89 percent of the salary cap in contract dollars, while overall league spending must average 95 percent in that span. That sort of minimum cash spending did not exist under the old CBA.

Another significant change under this agreement: owners and players divide types of revenues at different rates. Players receive 55 percent of revenue from the league's national TV and other media deals; 45 percent of licensing and national sponsorship deals, including NFL Properties; and 40 percent of local club revenues.

Source: http://news.yahoo.com/ap-source-salary-cap-increases-123-million-000007345--nfl.html

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Possible treatment window for memory problems identified

Feb. 27, 2013 ? Researchers have identified a possible treatment window of several years for plaques in the brain that are thought to cause memory loss in diseases such as Alzheimer's. The Mayo Clinic study is published in the Feb. 27 online issue of Neurology, the medical journal of the American Academy of Neurology.

"Our study suggests that plaques in the brain that are linked to a decline in memory and thinking abilities, called beta amyloid, take about 15 years to build up and then plateau," says lead author Clifford Jack, Jr., M.D., a Mayo Clinic radiologist, and the Alexander Family Professor of Alzheimer's Disease Research at Mayo Clinic.

For the study, 260 people ages 70 to 92 had two or more brain scans over an average of 1.3 years to measure plaque buildup in their brains. Of the participants, 22 percent had impaired thinking abilities or memory at the start of the study.

The study found that the rate of buildup accelerates initially, then slows before plateauing at high levels. The rate of plaque accumulation was highest in those with mid-range levels at the start of the study. Those with low levels or high levels of the plaques as the study began had lower rates of plaque buildup.

The study also found that the rate of buildup of plaques was more closely tied to the total amount of amyloid plaques in the brain than other risk factors, such as the level of cognitive impairment, age and the presence of the APOE gene, a gene linked to Alzheimer's disease.

"Our results suggest that there is a long treatment window where medications may be able to help slow buildup of the amyloid plaques that are linked to cognitive decline," Dr. Jack says. "On the other hand, trying to treat the plaque buildup after the amyloid plaque load has plateaued may not do much good."

The study was supported by the National Institutes of Health, National Institute on Aging (grant numbers R01 AG011378 and RO1 AG041851) and General Electric Corporation.

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The above story is reprinted from materials provided by Mayo Clinic.

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Journal Reference:

  1. Clifford R. Jack, Jr, Heather J. Wiste, Timothy G. Lesnick, Stephen D. Weigand, David S. Knopman, Prashanthi Vemuri, Vernon S. Pankratz, Matthew L. Senjem, Jeffrey L. Gunter, Michelle M. Mielke, Val J. Lowe, Bradley F. Boeve, and Ronald C. Petersen. Brain ?-amyloid load approaches a plateau. Neurology, 2013; DOI: 10.1212/WNL.0b013e3182840bbe

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/vyPoZqFYOto/130227161941.htm

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Ralph Bakshi's Kickstarter movie needs your help | Inside Movies ...

Last-Days-Background-Art

Image Credit: ART BY RALPH BAKSHI copyright Bakshi Productions, Inc.

?Hey people, Ralphie needs money to draw. Let?s give him some so he can make a fool of himself again.? ? Ralph Bakshi?s Miss America, in the Kickstarter campaign video for his new animated project

Making films has never been easy for Ralph Bakshi. The maverick cartoonist and filmmaker, who became famous ? and infamous ? after 1972?s smash X-rated ?toon, Fritz the Cat, never liked to color within the lines, so to speak. He was the anti-Disney back then, filling his stories with provocative themes, raunchy humor, and curvacious broads that would make Russ Meyer blush. His bold 1975 blaxploitation satire Coonskin was driven from some theaters by critics who deemed its racial elements offensive, but filmmakers like Quentin Tarantino adored the film, and Bakshi?s artistic style and spirit lived on in the work of admirers who went on to make cartoons like The Simpsons, Ren & Stimpy, and Rango.

Now 74 years old, Bakshi has been in exile for more than a decade, focusing on his painting at his New Mexico home after one-too-many frustrating and disappointing Hollywood experiences. He hasn?t made a feature film since 1992?s Cool World, and he seemed to call it quits for good after his short-lived HBO series Spicy City went belly-up in 1997. But he still has a story to tell ? a great one, he says, that will ?push the boundaries of 2-D animation.?

Last month, Bakshi set up a Kickstarter campaign to raise $165,000 for an animated short called, The Last Days of Coney Island, the first of a series he says he?s always wanted to make. Set in Brooklyn?s iconic boardwalk town in the 1960s, Coney Island has all the markings of a classic Bakshi joint: simmering, subliminal politics, fever-dream animation, and outrageous characters. His collage of a Brooklyn street (above, and here in supersize) captures his new style of combining cut-up photographs and paintings. ?It?s the best thing I?ve ever done,? Bakshi says, who aspires to hold a fun-house mirror up to America to show, as he says in the semi-NSFW Kickstarter video ?who we are, what we are, even if it hurts.?

With only three days to go, Bakshi?s team, which now includes Matthew Modine as the voice of Coney Island?s lead character, is close to reaching that financial goal ? but time is running out. Bakshi is a man of many contradictions, and his wounds from his legendary Hollywood battles ? Fritz, Lord of the Rings, Cool World ? are still raw. He spoke to Entertainment Weekly about his career, why he thinks Peter Jackson owes him at least a drink, and how Kickstarter opened the door to his potential comeback.

ENTERTAINMENT WEEKLY: You haven?t directed a film in 20 years, but I know this is a story that?s close to your heart. How long have these characters been bouncing around your head?
RALPH BAKSHI: Studs Terkel did a wonderful series of books that I used to read back in the ?60s. He interviewed various people: hookers and gangsters. It was a wonderful book that was so honest; the way people spoke about their jobs and their lives was fascinating to me. There was an authenticity that I thought animation could use. All these various people who come and go in my films ? I love to discuss their lives, or fantasize about their lives. I?m a cartoonist, so a lot of the things that I talk about with these people have a lot to do with my own fears and hangups.

Fans of your previous work will certainly feel pangs of nostalgia when they see the character drawings on your Kickstarter page. How will these characters compare to the ones they already know and love?
I?d like to discuss now what has happened to America and all of us through these characters. This little short guy in Coney Island who thinks he?s James Dean and Marlon Brando and sings like Chet Baker, a total narcissistic a?hole; he represents the worst of us. He works for the mafia, which makes him a very special dwarf at Coney Island. Even the mafia doesn?t want to get the kickbacks from all the freaks and sideshow workers, so they?re his size and he pushes them around. But then he wants more and more, and finally he starts pushing around the mafia. And then he?s after the mafia guy?s wife. It shows what?s happened to this country; what starts out fun-like and we?re doing well, but then greed gets out of hand. I don?t have to tell you about the banking situation and the mortgage situation, and the great disparity between the rich and the poor. So this character will represent that; It?s never enough, I think I deserve everything, I think I?m better than you. And the cops and all the other people who work with him or don?t work with him or get hurt by him show the other type of people who cave in when they shouldn?t cave in. I think people will recognize the various types that I?m portraying in the new America.

Coney Island is practically your childhood backyard. You grew up in Brooklyn, yes?
Coney Island was a wonderful place, full of excitement. Everything was a nickel: hot dogs were a nickel, rides were a nickel. It was a great place ? but it was awful at night. Almost illusionary, the gaudy backgrounds and the crowds. You had the dancers and strippers and snake charmers out on platforms, with the barker pulling people in to see the shows. It was quite strange, especially when I was 8, 9, 10. It?s a freaky fun house ? a great landscape for me to work against. How you going to animate Coney Island wrong? It allows you a great palette to explore and certainly in animation, you take it to the extent you want to as an artist.

What?s your hope for the finished product? On your site, you say you?re aiming to raise enough money for a seven-minute short?
I would go to 12 minutes if the money comes in. The extent of the short is based on how much money I can raise. Then I can show that to studios or producers and say, ?Look, you?re enjoying this. Let?s finish it.? I did Fritz the Cat and Heavy Traffic, and my pictures still play. So if it?s a good movie from a guy who hasn?t done a movie in 20 years, it can?t miss turning a dollar with a worldwide market.

I?m guessing you tried to go the studio route first before you turned to Kickstarter.
Yes. I showed them scripts and drawings. I was very much prepared for their game. But basically, [my movie is] non-merchandizable and they?re in the family-film business. And they want the computer-rendered characters. They pretty much said, ?Take your script and get the f?k out of here. Hit the road, Jack.? Same sh-t I started with [years ago]. Listen, I?m 74 years old. The things I said to these guys I?ve waited my whole life to tell them, that they don?t know what they?re talking about. They don?t have the slightest idea. I?m sorry, I can?t help it. Sh-t. That?s why I never sold anything.

NEXT: What really happened during the making of Cool World?

Source: http://insidemovies.ew.com/2013/02/28/ralph-bakshi-last-days-of-coney-island/

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Tweets allow peek at life in NKorea in real time

"Hello world from comms center in (hash)Pyongyang."

That Twitter missive, sent Monday from Koryolink's main service center in downtown Pyongyang using my iPhone, marked a milestone for North Korea: It was believed to be the first tweet sent from a cellphone using the country's new 3G mobile data service.

Later, as we were driving through Pyongyang, I used my iPhone to snap a photo of a new roadside banner referring to North Korea's controversial Feb. 12 nuclear test while AP's Chief Asia photographer David Guttenfelder uploaded an image to Instagram of a tour guide at a mountain temple, geotagged to Pyongyang.

Pretty ordinary stuff in the world of social media, but revolutionary for North Korea, a country with intricate rules to stage manage the flow of images and information both inside and beyond its borders.

In the past, rules were strict for tourists visiting North Korea. On a bus journey across the Demilitarized Zone into the border city of Kaesong in 2008, we were told: No cellphones, no long camera lenses, no shooting photos without permission. The curtains were drawn to prevent us from looking outside as we drove through the countryside, and through the cracks we could see soldiers stationed along the road with red flags. We were warned they'd raise those flags and stop the bus for inspection if they spotted a camera pointed out the window. As we left North Korea, immigration officials went through our cameras, clicking through the photos to make sure we weren't taking home any images that were objectionable.

In 2009, I did not offer up my iPhone as we went through customs. But to no avail. The eagle-eyed officer dug deep into the pocket where I'd tucked the phone away, wagged his finger and slipped the phone into a little black bag. No phone, no address book, no music: It was as though I'd left the modern world behind at Sunan airport and stepped back in time to a seemingly prehistoric analog era.

Eventually, Guttenfelder and I settled into a working routine. We'd leave our cellphones at the airport but use locally purchased phones with SIM cards provided by Koryolink, the joint Egyptian-North Korean cellphone venture that established a 3G network in 2008, but without data. We brought iPod Touches and connected to the world, including Twitter, using broadband Internet that may be installed on request at our hotel, which is for international visitors.

We knew in January that change was afoot. "Bring your own phone next time," a Koryolink saleswoman told me at the airport as we were departing. The next day, the longstanding rule of requiring visitors to relinquish their phones was gone.

But we were waiting for the day when Koryolink would begin offering mobile Internet, and hounded the Egyptians posted to North Korea from Orascom Telecom Media and Technology for news.

"Soon," they kept telling us.

Last week, they called with good news: 3G mobile Internet would be available within a week ? only for foreigners.

All we had to do when we arrived in February was show our passports, fill out a registration form, provide our phones' IMEI numbers and pop in our Koryolink SIM cards. It's a costly luxury: SIM cards are 50 euros, or about $70, and while calls to Switzerland are an inexplicably cheap 38 euro cents a minute, calls to the U.S. cost about $8 a minute.

After reporting last week on the imminent availability of 3G mobile Internet, we turned up at the Koryolink offices Monday to be among the first ones to activate the service.

After paying a steep 75-euro fee and sending a text to activate the service, we waited for the 3G symbol to pop up on our phones.

Moments later, I sent the inaugural tweet, which was queued up and ready to go. There was a little celebration that morning in the Koryolink office among the Egyptians who labored to set up the service and their North Korean partners.

Our North Korean colleagues watched with surprise as we showed them we could surf the Internet from our phones.

Koreans, North and South, love gadgets.

Not all North Koreans have local cellphones. Those who do use them to call colleagues to arrange work meetings, phone and text friends to set up dinner dates and ring home to check in on their babies. They snap photos with their phones and swap MP3s. They read North Korean books and the Workers' Party newspaper, Rodong Sinmun, on their phones.

But they cannot surf the "international" Internet, as they call it. The World Wide Web remains strictly off limits for most North Koreans. North Korean universities have their own fairly sophisticated Intranet system, though the material posted to it is closely vetted by authorities and hews to propaganda. Students say they can email one another, but they can't send emails outside the country.

Leader Kim Jong Un has pushed science and technology as major policy directives, and we're starting to see more laptops in North Korean offices. The new Samjiyon tablet computer, made in China for the North Korean market, was sold out when I last checked at a local computer shop.

Even during the days when no mobile data were available, Guttenfelder figured out a way to activate Wi-Fi sharing among his laptop, iPod touch and iPhone, and began posting geotagged pictures to Instagram. Using Loopcam, I began uploading small GIF videos that have the feel of an old-fashioned flipbook, giving movement and life to the scene on the street.

These are snapshots captured as we go about our daily life working in North Korea: a man getting a haircut at a barber shop, traffic cops lacing up ice skates, a villager hauling a bundle of firewood on her back as she trudges through a snowy field. Some are quirky, unexpected things that catch our attention: a blinking Christmas tree in February, the cartoon "Madagascar" showing on state TV, a basket of baguettes at the supermarket.

And some are politically telling: the empty highway from Pyongyang, people piling onto trucks for transportation, postcards showing soldiers attacking Americans, banners praising the scientists who sent a rocket into space. Despite the new construction, gadgets and consumer goods, North Korea is still grappling with grave economic hardship. It's a society governed by a web of strict rules and regulations, a nation wary of the outside world.

Often, they are images, videos and details that may not make it onto the AP's products but provide a behind-the-scenes glimpse of a country largely hidden from view even in our globalized, interconnected world. They help give a sense of the feel, smell and look of the place away from the pomp of the orchestrated events shown by the state media. It is a way for us to share what we see, large and small, during our long stays in a nation off limits to most Western journalists and still largely a mystery, even to us.

On Monday evening, while discussing how to cover the arrival of ex-NBA star Dennis Rodman and describing his array of tattoos and nose rings, we did what wasn't possible in the past: We Googled him from a local restaurant.

Twenty-four hours later, Rodman himself appeared to be online and tweeting from North Korea.

"I come in peace. I love the people of North Korea!" he wrote.

___

Jean H. Lee is the AP's bureau chief for North Korea and South Korea, and has made more than 20 trips to North Korea since 2008. Follow (at)newsjean on Twitter, Loopcam and Instagram. Follow (at)dguttenfelder on Twitter and Instagram.

Source: http://news.yahoo.com/tweets-allow-peek-life-nkorea-real-time-185922974.html

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